Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.61 |
| ▸ | LMNA | P02545 | 9/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 8/20 | 0.61 |
| ▸ | HTT | P42858 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 3/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815912 | 0.84 | MAPT (0.60) | MAPTLMNAALOX12HTTMEN1 | |
| SCHEMBL6814722 | 0.84 | MAPT (0.64) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6815382 | 0.82 | MAPT (0.61) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL6814682 | 0.82 | ALDH1A1 (0.79) | MAPTLMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL6816140 | 0.81 | MAPT (0.63) | MAPTLMNAALOX12MEN1KMT2A | |
| SCHEMBL6816662 | 0.81 | MAPT (0.57) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL6816001 | 0.81 | MAPT (0.57) | MAPTLMNAALOX12HTTMEN1 | |
| SCHEMBL6811687 | 0.81 | MAPT (0.57) | MAPTLMNAALOX12MEN1KMT2A | |
| SCHEMBL6811443 | 0.80 | MAPT (0.58) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6815539 | 0.80 | ALDH1A1 (0.64) | MAPTLMNAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137632-B1 | THIOUREA INHIBITORS OF HERPES VIRUSES | WYETH CORP (US) | 2004-07-28 | — | — | EP | disclosed |
| EP-1137645-B1 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | WYETH CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6426355-B1 | VIRICIDES; PREVENTION PRODUCTION | AMERICAN HOME PRODUCTS | 2002-07-30 | — | — | US | disclosed |
| US-6262090-B1 | Aminopyridine-containing thiourea inhibitors of herpes viruses | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-17 | — | — | US | disclosed |