Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113184 | 0.88 | AURKA (0.50) | AURKACHUKCHEK1CHEK2EGFR | |
| Hydrochloric Acid SCHEMBL6671780 | 0.81 | CHUK (0.45) | CHUKARMEN1KMT2AL3MBTL1 | |
| SCHEMBL6881920 | 0.80 | AURKA (0.56) | AURKACHUKKMT2ACHEK1EGFR | |
| SCHEMBL31219008 | 0.80 | AURKA (0.56) | AURKACHUKKMT2ACHEK1EGFR | |
| SCHEMBL6823229 | 0.78 | MEN1 (0.48) | CHUKARMEN1KMT2AEGFR | |
| SCHEMBL23852137 | 0.77 | AURKA (0.54) | AURKACHUKMEN1KMT2AL3MBTL1 | |
| SCHEMBL6819649 | 0.76 | KIT (0.48) | CHUKEGFR | |
| SCHEMBL17635013 | 0.75 | LRRK2 (0.56) | CHEK1CHEK2KDM4EMAPT | |
| SCHEMBL6647898 | 0.74 | LRRK2 (0.60) | CHEK1CHEK2KDM4EALDH1A1 | |
| SCHEMBL6825079 | 0.74 | NTRK1 (0.44) | AURKACHUKARMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058764-A1 | 4-PHENYL-PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-07-15 | — | — | WO | disclosed |