Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31219008 | 1.00 | AURKA (0.56) | AURKAUTS2RMAP2K7ABL1EGFR | |
| SCHEMBL23885518 | 0.85 | MAP2K7 (0.48) | AURKAUTS2RMAP2K7ABL1EGFR | |
| SCHEMBL23852137 | 0.83 | AURKA (0.54) | AURKAEGFRGSK3BJAK2ALDH1A1 | |
| SCHEMBL7218007 | 0.80 | AURKA (0.65) | AURKAEGFRPDGFRBDYRK1AALDH1A1 | |
| SCHEMBL6819930 | 0.80 | AURKA (0.50) | AURKAEGFRGSK3BCHEK1RET | |
| SCHEMBL31705964 | 0.80 | AURKA (0.50) | AURKAEGFRALDH1A1KDM4EMAPT | |
| SCHEMBL30672219 | 0.79 | EGFR (0.57) | AURKAABL1EGFRABL2CHEK1 | |
| SCHEMBL2389718 | 0.79 | EGFR (0.57) | AURKAABL1EGFRABL2CHEK1 | |
| SCHEMBL31705582 | 0.79 | AURKA (0.49) | AURKAMAP2K7ALDH1A1KDM4EMAPT | |
| SCHEMBL28603330 | 0.79 | AURKA (0.49) | AURKAMAP2K7EGFRGSK3BRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024199444-A1 | HETEROAROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海翊维康医药有限责任公司 | 2024-10-03 | — | — | WO | disclosed |
| WO-2011056739-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |