SCHEMBL6819984

SCHEMBL6819984

FC(F)c1ccc2cc(Br)ccc2c1C(Cl)Cl

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.35
CYP2A6 P11509 1/20 0.34
MEN1 O00255 2/20 0.32
MAPT P10636 2/20 0.32
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
NCEH1 Q6PIU2 2/20 0.32
SIRT2 Q8IXJ6 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823273 0.88 TYMS (0.32) CYP2A6
SCHEMBL6820123 0.88 ERN1 (0.38) ERN1CYP2A6MEN1MAPTKMT2A
SCHEMBL6819911 0.88 ERN1 (0.38) ERN1CYP2A6MEN1MAPTKMT2A
SCHEMBL6819304 0.87 ERN1 (0.35) ERN1CYP2A6MEN1MAPTKMT2A
SCHEMBL6815878 0.75 TDP2 (0.30)
SCHEMBL6823596 0.75 CYP2A6 (0.34) CYP2A6MEN1MAPTKMT2AKDM4E
SCHEMBL6819887 0.75 CYP2A6 (0.34) CYP2A6MEN1MAPTKMT2AKDM4E
SCHEMBL6823206 0.75 TYMS (0.32) CYP2A6
SCHEMBL6822909 0.71 PARP1 (0.33)
SCHEMBL6819375 0.69 ERN1 (0.59) ERN1CYP2A6MEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0995734-B1 Method for production of halogen-containing aromatic compound NIPPON CATALYTIC CHEM IND (JP) 2004-05-12 EP disclosed
US-6433231-B2 BROMINATION THE CORRESPONDING NAPHTHALENE HALOGEN COMPOUND NIPPON SHOKUBAI CO., LTD. (JP) 2002-08-13 US disclosed
US-20010045350-A1 Method for production of halogen-containing aromatic compound NIPPON SHOKUBAI CO., LTD., A JAPAN CORPORATION 2001-11-29 US disclosed
US-6288290-B1 BROMINATION AND PHOTOBROMINATION OF AROMATIC COMPOUNDS NIPPON SHOKUBAI, CO., LTD. (JP) 2001-09-11 US disclosed
EP-0995734-A1 Method for production of halogen-containing aromatic compound Nippon Shokubai Co., Ltd. (JP) 2000-04-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010045350-A1 Method for production of halogen-containing aromatic compound CBR1, CBR3, DCXR ERN1 1246/4885CYP2A6 989/4885MEN1 4761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.