Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309652 | 1.00 | S1PR2 (0.53) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL6820062 | 1.00 | S1PR2 (0.53) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL28779881 | 0.94 | S1PR2 (0.59) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL7310306 | 0.94 | S1PR2 (0.59) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL7303426 | 0.92 | S1PR2 (0.62) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL1177666 | 0.88 | ANPEP (0.53) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL4969986 | 0.88 | ANPEP (0.53) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL1568623 | 0.88 | ANPEP (0.53) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL3266047 | 0.87 | S1PR2 (0.59) | S1PR2S1PR4S1PR1S1PR3GRIK1 | |
| SCHEMBL25741921 | 0.86 | S1PR2 (0.55) | S1PR2S1PR4S1PR1S1PR3GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876388-B1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LAB (US) | 2004-02-18 | — | — | EP | disclosed |
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0876388-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |
| WO-1997017356-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-05-15 | — | — | WO | disclosed |