Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820275 | 1.00 | HTR1A (0.98) | HTR1ASLC6A4 | |
| Robalzotan SCHEMBL4811762 | 0.99 | HTR1A (1.00) | HTR1ASLC6A4 | |
| Robalzotan SCHEMBL115079 | 0.99 | HTR1A (1.00) | HTR1ASLC6A4 | |
| Robalzotan SCHEMBL6315984 | 0.92 | HTR1A (0.87) | HTR1ASLC6A4 | |
| SCHEMBL7619191 | 0.89 | HTR1A (0.78) | HTR1ASLC6A4 | |
| SCHEMBL7619185 | 0.89 | HTR1A (0.78) | HTR1ASLC6A4 | |
| Robalzotan SCHEMBL31060340 | 0.88 | HTR1A (0.80) | HTR1ASLC6A4 | |
| SCHEMBL7616883 | 0.88 | HTR1A (0.80) | HTR1ASLC6A4 | |
| SCHEMBL7616889 | 0.88 | HTR1A (0.80) | HTR1ASLC6A4 | |
| SCHEMBL27439215 | 0.85 | HTR1A (0.71) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021183-B1 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-0822813-B1 | A COMBINATION OF A 5-HT UPTAKE INHIBITOR WITH A SELECTIVE 5-HT 1A ANTAGONIST | ASTRAZENECA AB (SE) | 2002-04-24 | — | — | EP | claimed |
| EP-0725779-B1 | NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | claimed |
| US-6159972-A | Combination of a selective 5-HT1A antagonist and a selective ub. h5-HT.s1B antagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | claimed |
| US-5962514-A | Combination of 5-HT uptake inhibitor with a selective 5-HT1A antagonist | ASTRA AKTIEBOLAG (SE) | 1999-10-05 | — | — | US | claimed |
| US-5616610-A | CENTRAL NERVOUS SYSTEM DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-04-01 | — | — | US | claimed |
| EP-1021183-B1 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-0822813-B1 | A COMBINATION OF A 5-HT UPTAKE INHIBITOR WITH A SELECTIVE 5-HT 1A ANTAGONIST | ASTRAZENECA AB (SE) | 2002-04-24 | — | — | EP | disclosed |
| EP-0725779-B1 | NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES | ASTRAZENECA AB (SE) | 2001-07-11 | — | — | EP | disclosed |
| CN-1062269-C | Novel(R)-5-carbamyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyranes | ASTRA AKTIEBOLAY (SE) | 2001-02-21 | — | — | CN | disclosed |
| US-6159972-A | Combination of a selective 5-HT1A antagonist and a selective ub. h5-HT.s1B antagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | disclosed |
| US-5962514-A | Combination of 5-HT uptake inhibitor with a selective 5-HT1A antagonist | ASTRA AKTIEBOLAG (SE) | 1999-10-05 | — | — | US | disclosed |
| US-5616610-A | CENTRAL NERVOUS SYSTEM DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-04-01 | — | — | US | disclosed |
| CN-1136811-A | Novel(R)-5-carbamyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyranes | ASTRA AB (SE) | 1996-11-27 | — | — | CN | disclosed |