Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PGD | P52209 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554691 | 1.00 | MAPK1 (0.42) | MAPK1NPSR1GAAPGDCA2 | |
| SCHEMBL12638787 | 1.00 | MAPK1 (0.42) | MAPK1NPSR1GAAPGDCA2 | |
| SCHEMBL7551362 | 1.00 | MAPK1 (0.42) | MAPK1NPSR1GAAPGDCA2 | |
| SCHEMBL18219198 | 0.90 | SUCNR1 (0.38) | MAPK1NPSR1GAAPGD | |
| SCHEMBL18219558 | 0.90 | SUCNR1 (0.38) | MAPK1NPSR1GAAPGD | |
| SCHEMBL16639432 | 0.85 | MAPK1 (0.37) | MAPK1NPSR1GAAPGD | |
| SCHEMBL14944924 | 0.85 | MAPK1 (0.37) | MAPK1NPSR1GAAPGD | |
| SCHEMBL16488404 | 0.85 | MAPK1 (0.37) | MAPK1NPSR1GAAPGD | |
| SCHEMBL14944925 | 0.85 | MAPK1 (0.37) | MAPK1NPSR1GAAPGD | |
| SCHEMBL16883364 | 0.84 | MAPK1 (0.34) | MAPK1NPSR1PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835693-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-01-09 | — | — | US | disclosed |
| US-8324284-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-12-04 | — | — | US | disclosed |
| US-8202911-B2 | Migrastatin analog compositions and uses thereof | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-20110281916-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110263653-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-10-27 | — | — | US | disclosed |
| US-7939685-B2 | Hydroxylation of β-dicarbonyls with zirconium catalysts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-05-10 | — | — | US | disclosed |
| US-20100185014-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | FMC CORPORATION | 2010-07-22 | — | — | US | disclosed |
| US-7718818-B2 | Hydroxylation of beta-dicarbonyls with zirconium catalysts | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080306259-A1 | HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS | FMC CORPORATION | 2008-12-11 | — | — | US | disclosed |
| US-7414157-B2 | Hydroxylation of β-dicarbonyls with zirconium catalysts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100185014-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | CBR3, CBR1, NOXO1 | MAPK1 2715/4885NPSR1 2848/4885GAA 1713/4885 |
| US-20110281916-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | KDR, HMGCR, LPAR3 | MAPK1 3044/4885NPSR1 1070/4885GAA 3581/4885 |
| US-20080306259-A1 | HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS | CBR3, CBR1, ASPH | MAPK1 2394/4885NPSR1 2866/4885GAA 1196/4885 |
| US-20110263653-A1 | MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF | C3AR1, C1R, MRPS18A | MAPK1 3256/4885NPSR1 1350/4885GAA 3295/4885 |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | KDR, HMGCR, LPAR3 | MAPK1 3044/4885NPSR1 1070/4885GAA 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.