Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244955 | 0.80 | CDK2 (0.57) | CDK2CCNE1CCNE2CDK5CDK1 | |
| SCHEMBL6821034 | 0.78 | NT5E (0.49) | CDK2CCNE1CCNE2CDK1NT5E | |
| SCHEMBL6824057 | 0.76 | FLT3 (0.58) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL6824059 | 0.76 | FLT3 (0.58) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL6817986 | 0.75 | FLT3 (0.57) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| Hydrochloric Acid SCHEMBL6817990 | 0.75 | FLT3 (0.57) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL6817817 | 0.74 | NT5E (0.51) | CDK1NT5E | |
| SCHEMBL3296793 | 0.74 | CDK2 (0.67) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL17628635 | 0.74 | CDK2 (0.59) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL539356 | 0.74 | CDK2 (0.56) | CDK2CCNE1CDK5CDK5R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056745-B1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMA INC (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1056745-A2 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043676-A2 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |