SCHEMBL6821086

SCHEMBL6821086

CN1CCC(Oc2cc(NS(=O)(=O)c3ccc(Sc4cc(Cl)cc(Cl)c4)cc3Cl)ccc2Cl)C1

nearest known ligand 0.64

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 12/20 0.64
HTR6 P50406 2/20 0.39
SGK1 O00141 2/20 0.38
PPARG P37231 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823477 0.92 UTS2R (0.63) UTS2RHTR6SGK1PPARG
SCHEMBL6823471 0.92 UTS2R (0.63) UTS2RHTR6SGK1PPARG
SCHEMBL6821363 0.90 UTS2R (0.63) UTS2RHTR6SGK1
SCHEMBL6821370 0.90 UTS2R (0.63) UTS2RHTR6SGK1
SCHEMBL6820854 0.90 UTS2R (0.63) UTS2RPPARG
SCHEMBL6820857 0.90 UTS2R (0.63) UTS2RPPARG
SCHEMBL6823983 0.87 UTS2R (0.64) UTS2RSGK1PPARG
SCHEMBL6823993 0.87 UTS2R (0.64) UTS2RSGK1PPARG
SCHEMBL8342093 0.87 UTS2R (0.69) UTS2RSGK1PPARG
SCHEMBL6823990 0.86 UTS2R (0.57) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed