SCHEMBL6823477

SCHEMBL6823477

CN1CCC(Oc2cc(NS(=O)(=O)c3ccc(Sc4ccc(F)c(Cl)c4)cc3Cl)ccc2Cl)C1

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 11/20 0.63
THRB P10828 1/20 0.41
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTR6 P50406 2/20 0.39
HTR2C P28335 2/20 0.39
DRD2 P14416 1/20 0.39
HTR2A P28223 1/20 0.39
DRD3 P35462 1/20 0.39
SGK1 O00141 1/20 0.39
EGFR P00533 1/20 0.39
PPARG P37231 1/20 0.39
HTR2B P41595 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823471 1.00 UTS2R (0.63) UTS2RTHRBHPGDSMN1; SMN2HTR6
SCHEMBL6821370 0.93 UTS2R (0.63) UTS2RHTR6HTR2CSGK1HTR2B
SCHEMBL6821363 0.93 UTS2R (0.63) UTS2RHTR6HTR2CSGK1HTR2B
SCHEMBL6821086 0.92 UTS2R (0.64) UTS2RHTR6SGK1PPARG
SCHEMBL6820947 0.91 UTS2R (0.63) UTS2RPPARG
SCHEMBL6820953 0.91 UTS2R (0.63) UTS2RPPARG
SCHEMBL6823990 0.87 UTS2R (0.57) UTS2RSMN1; SMN2
SCHEMBL6823982 0.87 UTS2R (0.57) UTS2RSMN1; SMN2
SCHEMBL6823993 0.86 UTS2R (0.64) UTS2RSGK1PPARG
SCHEMBL6823983 0.86 UTS2R (0.64) UTS2RSGK1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed