Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.50 |
| ▸ | CA2 | P00918 | 12/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818574 | 0.88 | SMN1; SMN2 (0.52) | CA1CA2KDM4EF13A1SMN1; SMN2 | |
| SCHEMBL10592850 | 0.74 | KDM4E (0.84) | KDM4EF13A1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9016571 | 0.74 | CA1 (0.69) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL6821024 | 0.73 | PPID (0.44) | CA1CA2CA12ALDH1A1LMNA | |
| SCHEMBL28112130 | 0.73 | SMN1; SMN2 (0.51) | CA1CA2SMN1; SMN2ALDH1A1 | |
| SCHEMBL11357071 | 0.72 | KDM4E (0.68) | CA2KDM4EF13A1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11471927 | 0.72 | KDM4E (0.68) | KDM4EF13A1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2715966 | 0.70 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7858 | 0.69 | KDM4E (0.69) | CA1CA2KDM4EF13A1CA9 | |
| SCHEMBL24138188 | 0.69 | KDM4E (0.64) | CA1CA2KDM4EF13A1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |