Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 10/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818487 | 0.87 | HPSE (0.56) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL6818596 | 0.87 | MAPT (0.56) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL6818220 | 0.84 | NPC1 (0.52) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL7063573 | 0.83 | HPSE (0.83) | HPSE | |
| SCHEMBL7063577 | 0.83 | HPSE (0.83) | HPSE | |
| SCHEMBL6821837 | 0.83 | NPC1 (0.67) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL7160520 | 0.83 | KDM4E (0.52) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL6822403 | 0.79 | NPC1 (0.48) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL1121567 | 0.78 | NPC1 (0.59) | HPSEKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL6818283 | 0.77 | NPC1 (0.62) | HPSEKDM4ENPC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004046122-A2 | BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-06-03 | — | — | WO | disclosed |