Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.84 |
| ▸ | MGAM | O43451 | 4/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | SI | P14410 | 3/20 | 0.60 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.60 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CD38 | P28907 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822261 | 1.00 | ABCG2 (0.84) | ABCG2MGAMPDE5AGAASI | |
| Macarangin SCHEMBL30234138 | 0.91 | ABCG2 (1.00) | ABCG2MGAMGAASIMGAM2 | |
| Macarangin SCHEMBL21065396 | 0.91 | ABCG2 (1.00) | ABCG2MGAMGAASIMGAM2 | |
| Gancaonin P SCHEMBL1170933 | 0.91 | MGAM (0.76) | ABCG2MGAMPDE5AGAASI | |
| SCHEMBL6822763 | 0.90 | PTPN1 (0.70) | ABCG2MGAMGAASIMGAM2 | |
| SCHEMBL6822762 | 0.90 | PTPN1 (0.70) | ABCG2MGAMGAASIMGAM2 | |
| SCHEMBL18037681 | 0.87 | MGAM (0.75) | ABCG2MGAMGAASIMGAM2 | |
| SCHEMBL18037680 | 0.87 | MGAM (0.75) | ABCG2MGAMGAASIMGAM2 | |
| SCHEMBL24075660 | 0.83 | MGAM (0.80) | ABCG2MGAMPDE5AGAASI | |
| SCHEMBL29833229 | 0.83 | MGAM (0.80) | ABCG2MGAMPDE5AGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737439-B2 | ACTIVE CANCER CHEMOPREVENTATIVE AND TREATING AGENTS IN MAMMALS, INCLUDING HUMANS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2004-05-18 | — | — | US | claimed |
| US-20030125377-A1 | Aromatase inhibitors from Broussonetia papyrifera | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS THE | 2003-07-03 | — | — | US | claimed |
| US-6737439-B2 | ACTIVE CANCER CHEMOPREVENTATIVE AND TREATING AGENTS IN MAMMALS, INCLUDING HUMANS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2004-05-18 | — | — | US | disclosed |
| US-20030125377-A1 | Aromatase inhibitors from Broussonetia papyrifera | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS THE | 2003-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125377-A1 | Aromatase inhibitors from Broussonetia papyrifera | CYP19A1, HSD17B11, CYP17A1 | ABCG2 873/4885MGAM 1782/4885PDE5A 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.