Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.75 |
| ▸ | CXCR1 | P25024 | 11/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706755 | 0.89 | CXCR1 (0.72) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL3716985 | 0.87 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL6823930 | 0.87 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL7490549 | 0.83 | CXCR2 (0.67) | CXCR2CXCR1MEN1KMT2ACX3CR1 | |
| SCHEMBL7492139 | 0.78 | CXCR2 (0.77) | CXCR2CXCR1CX3CR1ALDH1A1 | |
| SCHEMBL7487864 | 0.76 | CXCR2 (0.61) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL3706591 | 0.76 | CXCR2 (0.73) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL6822942 | 0.76 | CXCR2 (0.73) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL7491596 | 0.75 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL31061375 | 0.75 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |