Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 11/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716985 | 1.00 | CXCR2 (1.00) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL7492139 | 0.88 | CXCR2 (0.77) | CXCR2CXCR1CX3CR1GAA | |
| SCHEMBL6823110 | 0.87 | CXCR2 (0.75) | CXCR2CXCR1MEN1KMT2ANPC1 | |
| SCHEMBL6822942 | 0.84 | CXCR2 (0.73) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL3706591 | 0.84 | CXCR2 (0.73) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL6550734 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL1880282 | 0.83 | CXCR2 (0.70) | CXCR2CXCR1MEN1KMT2ALMNA | |
| SCHEMBL7487837 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL6550665 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL7553831 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |