Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 16/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6823244 | 0.89 | CACNA1B (0.54) | CACNA1B | |
| Hydrochloric Acid SCHEMBL6820471 | 0.87 | CACNA1B (0.53) | CACNA1BMAPTMEN1KMT2AHTR7 | |
| Hydrochloric Acid SCHEMBL6823843 | 0.76 | CACNA1B (0.53) | CACNA1B | |
| Hydrochloric Acid SCHEMBL6823740 | 0.76 | CACNA1B (0.53) | CACNA1B | |
| SCHEMBL5156506 | 0.74 | CACNA1B (0.61) | CACNA1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6824097 | 0.74 | CACNA1B (0.41) | CACNA1BHTR7 | |
| SCHEMBL5151508 | 0.73 | CACNA1B (0.64) | CACNA1BMEN1KMT2AHTR7 | |
| SCHEMBL6820359 | 0.71 | CACNA1B (1.00) | CACNA1B | |
| SCHEMBL5156308 | 0.71 | CACNA1B (0.59) | CACNA1BMEN1KMT2A | |
| SCHEMBL6823495 | 0.70 | CACNA1B (1.00) | CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004017966-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS IN THE TREATMENT OF CHRONIC AND ACUTE PAIN | IONIX PHARMACEUTICALS LIMITED (GB) | 2004-03-04 | — | — | WO | claimed |