Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.73 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820541 | 1.00 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6823466 | 0.85 | KMT2A (0.55) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6824044 | 0.85 | CXCR1 (0.76) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595180 | 0.84 | CXCR2 (1.00) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL31222305 | 0.84 | CXCR2 (1.00) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL3180203 | 0.83 | KMT2A (1.00) | KMT2AMEN1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL8373850 | 0.83 | KMT2A (0.75) | KMT2AMEN1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL5595104 | 0.83 | CXCR1 (0.80) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595009 | 0.82 | CXCR1 (0.84) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL18013179 | 0.79 | TRPV1 (0.76) | CXCR1CXCR2KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194143-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1194143-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076457-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |