Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.76 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595009 | 0.89 | CXCR1 (0.84) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595104 | 0.87 | CXCR1 (0.80) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL31222305 | 0.86 | CXCR2 (1.00) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595180 | 0.86 | CXCR2 (1.00) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL14514332 | 0.85 | KMT2A (0.64) | CXCR1CXCR2KMT2AMEN1RAF1 | |
| SCHEMBL6820541 | 0.85 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6823571 | 0.85 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6824074 | 0.84 | CXCR1 (0.76) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595137 | 0.84 | CXCR1 (0.76) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595105 | 0.83 | CXCR1 (0.70) | CXCR1CXCR2KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194143-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1194143-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076457-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0907362-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0907362-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049399-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |