Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 13/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67005 | 1.00 | CACNA1B (0.61) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL66877 | 1.00 | CACNA1B (0.61) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL2422009 | 0.83 | CACNA1B (0.72) | CACNA1BHTTCNR1LMNA | |
| SCHEMBL65843 | 0.81 | CACNA1B (0.63) | CACNA1B | |
| SCHEMBL3243304 | 0.80 | CACNA1B (0.64) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL66447 | 0.80 | CACNA1B (0.64) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL2454518 | 0.80 | CACNA1B (0.64) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL16498004 | 0.80 | CACNA1B (0.64) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL67290 | 0.80 | CACNA1B (0.64) | CACNA1BHTTGAAHPGDCNR1 | |
| SCHEMBL67088 | 0.78 | CACNA1B (0.75) | CACNA1BGAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129417-B2 | Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers | ABBOTT LABORATORIES (US) | 2012-03-06 | — | — | US | claimed |