Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.41 |
| ▸ | MTOR | P42345 | 12/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | PNLIP | P16233 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424905 | 0.73 | TYR (0.51) | TYRPIK3CAMTORSTK17BABCC2 | |
| SCHEMBL6824396 | 0.71 | TYR (0.58) | TYRPIK3CAMTORHDAC3HDAC4 | |
| SCHEMBL6824393 | 0.71 | TYR (0.58) | TYRPIK3CAMTORHDAC3HDAC4 | |
| SCHEMBL6820553 | 0.70 | TYR (0.55) | TYRPIK3CAMTORHDAC3HDAC4 | |
| SCHEMBL5707796 | 0.70 | TYR (1.00) | TYRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21199328 | 0.69 | TYR (0.72) | TYRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6820583 | 0.68 | TYR (0.44) | TYRPIK3CAMTOR | |
| SCHEMBL27492141 | 0.66 | TYR (0.66) | TYRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6823698 | 0.66 | TYR (0.43) | TYRPIK3CAMTORHDAC3HDAC4 | |
| SCHEMBL14008639 | 0.65 | TYR (0.51) | TYRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |