Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 7/20 | 0.63 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594971 | 0.92 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595233 | 0.89 | CXCR1 (0.68) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6824241 | 0.84 | HTT (0.62) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595010 | 0.84 | HTT (0.62) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5594844 | 0.75 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL6924667 | 0.75 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595289 | 0.75 | CXCR1 (0.73) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL7491012 | 0.75 | CXCR2 (0.70) | CXCR1CXCR2KMT2AMEN1TDP1 | |
| SCHEMBL5595167 | 0.75 | SMN1; SMN2 (0.74) | CXCR1CXCR2KMT2AMEN1HTT | |
| SCHEMBL6823516 | 0.75 | SMN1; SMN2 (0.74) | CXCR1CXCR2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |