Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708973 | 0.89 | CXCR1 (0.67) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL7495262 | 0.88 | CXCR2 (0.66) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL5595225 | 0.84 | MEN1 (0.60) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL1110610 | 0.84 | CXCR2 (1.00) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL29733649 | 0.84 | CXCR2 (1.00) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL29493172 | 0.84 | CXCR2 (1.00) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL6921874 | 0.84 | CXCR2 (1.00) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL5594971 | 0.79 | CXCR1 (0.73) | CXCR2MEN1KMT2ACXCR1TDP1 | |
| SCHEMBL6940403 | 0.79 | MAPT (0.61) | MEN1KMT2ATDP1MAPTLMNA | |
| SCHEMBL6943988 | 0.77 | MAPT (0.59) | MEN1KMT2ATDP1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |