Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595848 | 0.93 | MAPT (0.68) | MAPTERN1MAOBBACE1KMT2A | |
| SCHEMBL5595852 | 0.93 | MAPT (0.68) | MAPTERN1MAOBBACE1KMT2A | |
| SCHEMBL5595855 | 0.93 | MAPT (0.68) | MAPTERN1MAOBBACE1KMT2A | |
| SCHEMBL6785545 | 0.89 | MAPT (0.73) | MAPTERN1MAOBGPR35BACE1 | |
| SCHEMBL5595081 | 0.89 | MAPT (0.73) | MAPTERN1MAOBGPR35BACE1 | |
| SCHEMBL5595086 | 0.89 | MAPT (0.73) | MAPTERN1MAOBGPR35BACE1 | |
| SCHEMBL6823884 | 0.84 | MAPT (0.53) | MAPTERN1MAOBBACE1KMT2A | |
| SCHEMBL6823888 | 0.84 | MAPT (0.53) | MAPTERN1MAOBBACE1KMT2A | |
| O-Coumaric Acid SCHEMBL6824137 | 0.83 | MAPT (0.68) | MAPTERN1MAOBGPR35BACE1 | |
| O-Coumaric Acid SCHEMBL6824128 | 0.83 | MAPT (0.68) | MAPTERN1MAOBGPR35BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |