SCHEMBL6823949

SCHEMBL6823949

COc1cc(Nc2ncnc3cc(OCCN4CCN(C(C)=O)CC4)cc(OC(C)C)c23)c(Cl)cn1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRC P12931 20/20 0.77
KDR P35968 18/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829362 0.87 SRC (1.00) SRCKDR
SCHEMBL6829440 0.87 SRC (1.00) SRCKDR
SCHEMBL6921194 0.86 SRC (0.79) SRCKDR
SCHEMBL6825683 0.85 SRC (0.74) SRCKDR
SCHEMBL6924183 0.83 SRC (0.80) SRCKDR
Azd-0424 SCHEMBL3202072 0.83 SRC (0.73) SRCKDR
Azd-0424 SCHEMBL29382167 0.83 SRC (0.73) SRCKDR
SCHEMBL6922194 0.82 SRC (0.75) SRCKDR
SCHEMBL6819711 0.82 SRC (0.72) SRCKDR
SCHEMBL3194213 0.81 SRC (0.69) SRCKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056812-A1 4- (PYRIDIN-4-YLAMINO) -QUINAZOLINE DERIVATIVES AS ANTI-TUMOR AGENTS ASTRAZENECA AB (SE) 2004-07-08 WO disclosed