Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.69 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | RORC | P51449 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594986 | 1.00 | MEN1 (0.69) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL7485664 | 0.86 | CXCR1 (0.67) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL7488285 | 0.85 | CXCR1 (0.66) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595115 | 0.85 | MEN1 (0.63) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595104 | 0.85 | CXCR1 (0.80) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5594962 | 0.84 | MEN1 (0.72) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL7488086 | 0.83 | CXCR1 (0.63) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL27558243 | 0.83 | CXCR2 (0.61) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL7487951 | 0.83 | CXCR1 (0.63) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5594899 | 0.83 | KMT2A (0.63) | MEN1KMT2ACXCR1CXCR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |