Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 9/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823287 | 0.87 | CXCR2 (0.60) | CXCR2CXCR1HTTTRPV1MEN1 | |
| SCHEMBL27535605 | 0.83 | SMN1; SMN2 (0.39) | TRPV1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL3710835 | 0.81 | HTT (0.56) | CXCR2CXCR1HTTTRPV1MEN1 | |
| SCHEMBL27519344 | 0.77 | CXCR2 (0.37) | CXCR2CXCR1TDP1L3MBTL1 | |
| SCHEMBL6822942 | 0.77 | CXCR2 (0.73) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL3706591 | 0.77 | CXCR2 (0.73) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL7549667 | 0.76 | KDR (0.59) | HTTTRPV1MEN1KMT2AKDM4E | |
| SCHEMBL7549619 | 0.73 | MEN1 (0.56) | CXCR2TRPV1MEN1KMT2AKDM4E | |
| SCHEMBL27535606 | 0.70 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7484157 | 0.69 | CXCR2 (0.46) | CXCR2CXCR1HTTTRPV1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |