Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594826 | 0.89 | CXCR2 (0.57) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL3710835 | 0.86 | HTT (0.56) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL7490879 | 0.81 | ALDH1A1 (0.52) | CXCR2MEN1KMT2AFABP4KDM4E | |
| SCHEMBL7484160 | 0.81 | FABP4 (0.39) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL6823287 | 0.80 | CXCR2 (0.60) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL5595150 | 0.75 | HTT (0.56) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL5612816 | 0.73 | MEN1 (0.58) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL27556175 | 0.73 | CXCR2 (0.58) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL6820254 | 0.72 | HTT (0.52) | CXCR2CXCR1HTTMEN1KMT2A | |
| SCHEMBL5595207 | 0.72 | HTT (0.52) | CXCR2CXCR1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |