Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.69 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826873 | 0.94 | MAPK13 (0.66) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL6098072 | 0.88 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL6824435 | 0.86 | MAPK14 (0.79) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6824979 | 0.85 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6651799 | 0.85 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL27533902 | 0.84 | MAPK13 (0.47) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL6824404 | 0.83 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7642695 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL6824421 | 0.81 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6827035 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210325-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-10-06 | — | — | EP | disclosed |
| US-6750253-B1 | INHIBITION OR DOWN REGULATION OF THE CYTOKINES IS POSSIBLY DUE TO AN INHIBITION OF MAP KINASES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2004-06-15 | — | — | US | disclosed |
| EP-1210325-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001005751-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |