Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394624 | 0.84 | MAPK14 (0.70) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL27540950 | 0.84 | RAB9A (0.57) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6824435 | 0.83 | MAPK14 (0.79) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6395965 | 0.83 | MAPK14 (0.71) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6824421 | 0.83 | MAPK14 (0.74) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6097404 | 0.82 | MAPK14 (0.54) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6097395 | 0.82 | MAPK14 (0.54) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6824979 | 0.82 | MAPK14 (0.77) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6651799 | 0.82 | MAPK14 (0.84) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7642695 | 0.81 | MAPK14 (1.00) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210325-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-10-06 | — | — | EP | claimed |
| US-6750253-B1 | INHIBITION OR DOWN REGULATION OF THE CYTOKINES IS POSSIBLY DUE TO AN INHIBITION OF MAP KINASES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2004-06-15 | — | — | US | claimed |
| EP-1210325-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | claimed |
| WO-2001005751-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | claimed |
| EP-1210325-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-10-06 | — | — | EP | disclosed |
| US-6750253-B1 | INHIBITION OR DOWN REGULATION OF THE CYTOKINES IS POSSIBLY DUE TO AN INHIBITION OF MAP KINASES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2004-06-15 | — | — | US | disclosed |
| EP-1210325-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001005751-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |