Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 12/20 | 0.45 |
| ▸ | MAOB | P27338 | 12/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585048 | 0.79 | GAA (0.52) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL4080083 | 0.77 | VCP (0.59) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL2828957 | 0.73 | MEN1 (0.55) | KDM4EGAAMEN1MAPTKMT2A | |
| SCHEMBL2579091 | 0.72 | GAA (0.64) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL4728318 | 0.71 | VCP (0.49) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL2575950 | 0.71 | VCP (0.54) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL2825409 | 0.70 | NPC1 (0.57) | GAAMEN1MAPTKMT2AMAOA | |
| SCHEMBL28911474 | 0.70 | VCP (0.62) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL24590218 | 0.69 | GAA (0.59) | KDM4EVCPGAAMEN1MAPT | |
| SCHEMBL10918876 | 0.69 | KDM4E (0.74) | KDM4EVCPGAAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441719-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |