Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824188 | 0.94 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL6824376 | 0.90 | MAPK14 (0.81) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL6903370 | 0.88 | MAPK14 (0.59) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL7647816 | 0.87 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL6825252 | 0.87 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL6826625 | 0.86 | MAPK13 (0.66) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6824811 | 0.85 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6817151 | 0.84 | MAPK1 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL6825009 | 0.84 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6817149 | 0.84 | MAPK1 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210325-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-10-06 | — | — | EP | disclosed |
| US-6750253-B1 | INHIBITION OR DOWN REGULATION OF THE CYTOKINES IS POSSIBLY DUE TO AN INHIBITION OF MAP KINASES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2004-06-15 | — | — | US | disclosed |
| EP-1210325-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001005751-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |