Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647816 | 0.93 | MAPK13 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL27484493 | 0.93 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6817151 | 0.89 | MAPK1 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6817149 | 0.89 | MAPK1 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6909999 | 0.89 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6904625 | 0.88 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6824985 | 0.88 | MAPK13 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL1906733 | 0.88 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6395572 | 0.86 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6402341 | 0.85 | MAPK13 (0.50) | MAPK14MAPK13MAPK12MAPK11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |