SCHEMBL6825335

SCHEMBL6825335

CCCC1CCC2(CCN(C(=O)OC(C)(C)C)CC2)O1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
RECQL P46063 1/20 0.41
HPGD P15428 1/20 0.40
GPR119 Q8TDV5 2/20 0.39
EPHX1 P07099 1/20 0.39
NAMPT P43490 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PKM P14618 1/20 0.38
DDB1 Q16531 1/20 0.38
CRBN Q96SW2 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38
PDE4D Q08499 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15229254 0.86 USP2 (0.43) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL6822716 0.82 USP2 (0.40) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL1575074 0.80 USP2 (0.47) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL6747537 0.76 USP2 (0.46) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL12493355 0.75 USP2 (0.40) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL26630217 0.75 USP2 (0.45) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL17125240 0.74 GPR119 (0.43) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL792459 0.74 HPGD (0.54) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL13277798 0.74 USP2 (0.40) USP2SMN1; SMN2RECQLHPGDGPR119
SCHEMBL13604572 0.74 USP2 (0.44) USP2SMN1; SMN2RECQLHPGDGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004058763-A1 4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2004-07-15 WO disclosed