Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.63 |
| ▸ | PPARG | P37231 | 7/20 | 0.63 |
| ▸ | PPARD | Q03181 | 7/20 | 0.63 |
| ▸ | PPARA | Q07869 | 7/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TLR2 | O60603 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | FABP4 | P15090 | 2/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.63 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439674 | 1.00 | FFAR4 (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Adipic Acid SCHEMBL8045754 | 0.98 | AKR1B1 (0.61) | FFAR4FFAR1GPR84PPARGPPARD | |
| Butane SCHEMBL11501207 | 0.94 | ALDH1A1 (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Decanoic Acid SCHEMBL6374907 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Decanoic Acid SCHEMBL597983 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL18344245 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Stearic Acid SCHEMBL7176001 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Octanoic Acid SCHEMBL7178169 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Octanoic Acid SCHEMBL7178164 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD | |
| Palmitic Acid SCHEMBL597984 | 0.93 | GSR (0.65) | FFAR4FFAR1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076425-A1 | IMPROVED SYNTHESIS OF MACROCYCLIC TETRAAMIDO COMPOUNDS AND NEW METAL INSERTION PROCESS | CARNEGIE MELLON UNIVERSITY (US) | 2004-09-10 | — | — | WO | disclosed |
| US-6051704-A | REACTING AN AMINO CARBOXYLIC ACID WITH AN ACTIVATED DERIVATIVE SELECTED FROM THE GROUP CONSISTING OF OXALATES AND MALONATES IN THE PRESENCE OF A SUPPORTING SOLVENT AND HEAT TO FORM AN INTERMEDIATE, ADDING A DIAMINE, HEATING | CARNEGIE MELLON UNIVERSITY (US) | 2000-04-18 | — | — | US | disclosed |