⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25017994 | 0.70 | — | — | |
| SCHEMBL21366305 | 0.65 | MAPT (0.39) | — | |
| SCHEMBL18937731 | 0.65 | — | — | |
| SCHEMBL387432 | 0.64 | — | — | |
| SCHEMBL6003977 | 0.64 | RECQL (0.58) | — | |
| SCHEMBL3526724 | 0.61 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL24228128 | 0.61 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL1993425 | 0.61 | MAPK1 (0.43) | — | |
| SCHEMBL10765496 | 0.60 | — | — | |
| SCHEMBL10741341 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084064-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-13 | — | — | US | disclosed |
| US-12195445-B2 | 2-amino-N-heteroaryl-nicotinamides as Nav1.8 inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-01-14 | — | — | US | disclosed |
| CN-115884974-B | Process for preparing alkyl 7-amino-5-methyl- [1,2,5] oxadiazolo [3,4-b ] pyridinecarboxylic acid esters | 勃林格殷格翰国际有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-113272293-B | 2-Amino-N-heteroaryl-nicotinamide as NAV1.8 inhibitor | 默沙东有限责任公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-4153599-B1 | PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL-[1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE | BOEHRINGER INGELHEIM INT (DE) | 2024-03-13 | — | — | EP | disclosed |
| CN-115884974-A | Process for preparing alkyl 7-amino-5-methyl- [1,2,5] oxadiazolo [3,4-b ] pyridinecarboxylic acid esters | 勃林格殷格翰国际有限公司 | 2023-03-31 | — | — | CN | disclosed |
| EP-4153599-A1 | PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL-[1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE | Boehringer Ingelheim International GmbH (DE) | 2023-03-29 | — | — | EP | disclosed |
| US-11518771-B2 | Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-12-06 | — | — | US | disclosed |
| US-11518771-B2 | Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-12-06 | — | — | US | disclosed |
| US-20220289710-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2022-09-15 | — | — | US | disclosed |
| US-20210363156-A1 | PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL- [1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-11-25 | — | — | US | disclosed |
| US-20210363156-A1 | PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL- [1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-11-25 | — | — | US | disclosed |
| WO-2021233882-A1 | PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL-[1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-11-25 | — | — | WO | disclosed |
| EP-3873893-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2021-09-08 | — | — | EP | disclosed |
| CN-113272293-A | 2-amino-N-heteroaryl-nicotinamide as NAV1.8 inhibitors | 默沙东公司 | 2021-08-17 | — | — | CN | disclosed |
| US-20200140411-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-05-07 | — | — | US | disclosed |
| US-20200140411-A1 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-05-07 | — | — | US | disclosed |
| US-6740647-B1 | AMIDINES AND HYDROXYAMIDINE DERIVATIVES | ABBOTT GMBH & CO., KG (DE) | 2004-05-25 | — | — | US | disclosed |
| EP-1051431-A1 | THROMBIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037668-A1 | THROMBIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-29 | — | — | WO | disclosed |