Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.69 |
| ▸ | THRA | P10827 | 8/20 | 0.69 |
| ▸ | PPARG | P37231 | 7/20 | 0.69 |
| ▸ | RXRA | P19793 | 3/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.69 |
| ▸ | ITGAV | P06756 | 1/20 | 0.69 |
| ▸ | PCNA | P12004 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | TTR | P02766 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238467 | 0.91 | THRB (0.73) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL6825136 | 0.85 | THRB (0.85) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL16425259 | 0.82 | PCNA (0.68) | THRBTHRAPPARGRXRAITGB3 | |
| Tetrac SCHEMBL365951 | 0.82 | THRB (1.00) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL7764850 | 0.81 | MAPT (0.52) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL554462 | 0.79 | PCNA (0.62) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL14264006 | 0.79 | THRB (0.62) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL12440046 | 0.78 | PCNA (0.69) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL13886596 | 0.77 | THRB (0.60) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL3217395 | 0.77 | THRB (0.73) | THRBTHRAPPARGRXRAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398024-A2 | Uses for thyroid hormone compounds | KARO BIO AB (SE) | 2004-03-17 | — | — | EP | claimed |