Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 2/20 | 0.50 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824070 | 0.84 | MEN1 (0.54) | GAACXCR1CXCR2PTGESMEN1 | |
| SCHEMBL6922530 | 0.80 | TRPV1 (0.48) | ABCG2KIF11MEN1KMT2ATRPV1 | |
| SCHEMBL6826190 | 0.78 | CXCR1 (0.70) | P2RX1TMPRSS4ABCG2CA12CA1 | |
| SCHEMBL5595105 | 0.78 | CXCR1 (0.70) | P2RX1TMPRSS4ABCG2CA12CA1 | |
| SCHEMBL6920112 | 0.76 | MEN1 (0.46) | GAACXCR1CXCR2MEN1KMT2A | |
| SCHEMBL6301913 | 0.75 | MEN1 (0.74) | ABCG2CA12CA1CA2CA9 | |
| SCHEMBL6823879 | 0.74 | AKR1C3 (0.44) | P2RX1TMPRSS4GAACXCR1CXCR2 | |
| SCHEMBL7485993 | 0.74 | MEN1 (0.47) | P2RX1GAACXCR1CXCR2MEN1 | |
| SCHEMBL6823370 | 0.74 | KMT2A (0.55) | GAAMEN1KMT2ATRPV1LMNA | |
| SCHEMBL28330879 | 0.73 | MEN1 (0.68) | ABCG2MEN1KMT2ATRPV1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |