Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824070 | 0.77 | MEN1 (0.54) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL7485985 | 0.76 | CXCR2 (0.73) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL5595090 | 0.75 | CXCR1 (0.57) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL6826191 | 0.74 | P2RX1 (0.50) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL6823370 | 0.74 | KMT2A (0.55) | MEN1KMT2AMAPTLMNAPKM | |
| SCHEMBL6823794 | 0.71 | SMN1; SMN2 (0.52) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL6920949 | 0.71 | ALDH1A1 (0.56) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL6921876 | 0.71 | CXCR2 (0.66) | MEN1KMT2AMAPTCXCR1CXCR2 | |
| SCHEMBL6820172 | 0.70 | MEN1 (0.59) | MEN1KMT2AMAPTLMNAPKM | |
| SCHEMBL7539557 | 0.70 | KMT2A (0.55) | MEN1KMT2AMAPTCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |