Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.70 |
| ▸ | CHUK | O15111 | 10/20 | 0.70 |
| ▸ | CDK2 | P24941 | 1/20 | 0.70 |
| ▸ | BTK | Q06187 | 1/20 | 0.70 |
| ▸ | ITK | Q08881 | 1/20 | 0.70 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657089 | 0.89 | IKBKB (0.74) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL16794616 | 0.87 | IKBKB (0.72) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL6823205 | 0.87 | IKBKB (0.77) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL17074058 | 0.86 | IKBKB (0.74) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL5659822 | 0.86 | IKBKB (0.74) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL6823062 | 0.85 | IKBKB (0.72) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589469 | 0.85 | IKBKB (0.70) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL14589479 | 0.84 | IKBKB (0.76) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL5657205 | 0.83 | IKBKB (1.00) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL5658686 | 0.82 | IKBKB (0.80) | IKBKBCHUKCDK2BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004106293-A2 | OXAZOLYL - AND THIAZOLYL - PURINE BASED TRICYCLIC COMPOUNDS. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | claimed |