Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6827446 | 0.81 | CHEK1 (0.43) | PDGFRBLRRK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4858818 | 0.75 | CHEK1 (0.49) | PDGFRBKDRHRH3DRD4AKR1C3 | |
| SCHEMBL28387573 | 0.67 | TSHR (0.54) | HRH3PARP1DRD4DDB1CRBN | |
| SCHEMBL4855638 | 0.65 | SIGMAR1 (0.51) | SIGMAR1LRRK2KCNJ1 | |
| SCHEMBL15467001 | 0.65 | HRH3 (0.87) | HRH3AKR1C3ALDH1A1LMNAMAPT | |
| SCHEMBL5618352 | 0.65 | SMN1; SMN2 (0.71) | HRH3SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL532537 | 0.64 | DRD4 (0.72) | PARP1DRD4HTR1ACHRM5ADRA2A | |
| SCHEMBL15676971 | 0.62 | SMN1; SMN2 (0.51) | HRH3PARP1DRD4DRD2ALDH1A1 | |
| 4-(4-Chlorobenzyl)Morpholine SCHEMBL4103722 | 0.62 | HRH3 (0.74) | HRH3AKR1C3SIGMAR1ALDH1A1LMNA | |
| SCHEMBL28384046 | 0.62 | SMN1; SMN2 (0.48) | HRH3PARP1OTUD7BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | PDGFRB 694/4885KDR 952/4885HRH3 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.