Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CISD2 | Q8N5K1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828042 | 0.84 | MEN1 (0.48) | POLBCYP3A4HPGDMEN1KMT2A | |
| SCHEMBL6828207 | 0.83 | CYP3A4 (0.41) | POLBCYP3A4HPGDACHEMEN1 | |
| SCHEMBL6828033 | 0.81 | CYP3A4 (0.51) | POLBCYP3A4HPGDACHEMAPT | |
| SCHEMBL8869278 | 0.78 | CYP3A4 (0.46) | POLBCYP3A4HPGDACHECISD2 | |
| SCHEMBL16191707 | 0.78 | POLB (0.53) | POLBCYP3A4HPGDACHECISD2 | |
| SCHEMBL16096788 | 0.77 | NCEH1 (0.42) | POLBCYP3A4HPGDACHEMAPT | |
| SCHEMBL8272803 | 0.77 | CYP3A4 (0.46) | POLBCYP3A4HPGDACHECISD2 | |
| SCHEMBL23629413 | 0.77 | KDM4E (0.44) | POLBCYP3A4HPGDACHECISD2 | |
| SCHEMBL17187612 | 0.77 | CYP3A4 (0.50) | POLBCYP3A4HPGDACHECISD2 | |
| SCHEMBL29576643 | 0.77 | CYP3A4 (0.50) | POLBCYP3A4HPGDACHECISD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073612-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-09-02 | — | — | WO | disclosed |