Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746647 | 0.88 | RIPK1 (0.50) | POLBTACR1RIPK1DPP4DPP8 | |
| SCHEMBL5746649 | 0.88 | RIPK1 (0.50) | POLBTACR1RIPK1DPP4DPP8 | |
| SCHEMBL5747606 | 0.88 | RIPK1 (0.50) | POLBTACR1RIPK1DPP4DPP8 | |
| SCHEMBL6310814 | 0.88 | RIPK1 (0.50) | POLBTACR1RIPK1DPP4DPP8 | |
| SCHEMBL6207624 | 0.81 | RIPK1 (0.51) | RIPK1MEN1TSHRKMT2ALMNA | |
| SCHEMBL3376086 | 0.81 | RIPK1 (0.51) | RIPK1MEN1TSHRKMT2ALMNA | |
| SCHEMBL9295296 | 0.80 | KDM1A (0.56) | TSHRCYP3A4CYP2C19 | |
| SCHEMBL9295294 | 0.80 | KDM1A (0.56) | TSHRCYP3A4CYP2C19 | |
| SCHEMBL9295289 | 0.80 | KDM1A (0.56) | TSHRCYP3A4CYP2C19 | |
| SCHEMBL17454944 | 0.78 | RIPK1 (0.69) | POLBRIPK1MEN1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111000-A2 | PIPERIDYL DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2004-12-23 | — | — | WO | disclosed |