Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822894 | 0.84 | POLB (0.55) | PKMKDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL6828688 | 0.80 | KDM4E (0.62) | BRAFKDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL6826630 | 0.79 | KDM4E (0.60) | BRAFKDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL6826652 | 0.74 | ABCB1 (0.54) | KDM4EMAPTALDH1A1MAPK1POLB | |
| SCHEMBL31219113 | 0.72 | KDM4E (0.72) | KDM4EMAPTALDH1A1MAPK1POLB | |
| SCHEMBL17396514 | 0.72 | KDM4E (0.72) | KDM4EMAPTALDH1A1MAPK1POLB | |
| SCHEMBL6254106 | 0.71 | LIMK1 (0.65) | KDM4EMAPTALDH1A1MAPK1POLB | |
| SCHEMBL6826964 | 0.71 | KDM4E (0.50) | KDM4EMAPTALDH1A1MAPK1POLB | |
| SCHEMBL27829906 | 0.70 | BRAF (1.00) | BRAFPKMPDE3APLGPLAU | |
| Hydrochloric Acid SCHEMBL7221411 | 0.70 | LIMK1 (0.63) | KDM4EMAPTALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111052-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) | XENOVA LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |