SCHEMBL6828627

SCHEMBL6828627

O=C(O)c1sc(C(F)(F)F)cc1O.Oc1csc(C(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.37
GPR35 Q9HC97 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL833851 0.87 DAO (0.46) DAOGPR35
SCHEMBL1244370 0.78 DAO (0.30) DAO
SCHEMBL6828628 0.74 GSK3B (0.33)
SCHEMBL12153753 0.68 DAO (0.44) DAOGPR35
SCHEMBL281723 0.68 RAF1 (0.42)
SCHEMBL21986753 0.68 DAO (0.50) DAO
SCHEMBL4061102 0.65 PTPN1 (0.41) DAO
SCHEMBL6223675 0.64 DAO (0.39) DAO
SCHEMBL19436412 0.64 DAO (0.43) DAOGPR35
SCHEMBL16593960 0.62 DAO (0.39) DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1442030-A1 THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS ELI LILLY AND COMPANY (US) 2004-08-04 EP disclosed
WO-2003035629-A1 THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS ELI LILLY AND COMPANY (US) 2003-05-01 WO disclosed