Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 13/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829254 | 1.00 | CDK4 (0.59) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL6829794 | 0.91 | CDK2 (0.64) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL6826387 | 0.91 | CDK2 (0.64) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL6829108 | 0.91 | CDK2 (0.64) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL6829175 | 0.79 | SYK (0.83) | SYKCDK1IGF1RAURKAGSK3B | |
| SCHEMBL656179 | 0.78 | SYK (0.69) | CDK4SYKITKEGFRAURKA | |
| SCHEMBL6643046 | 0.77 | CDK4 (0.57) | CDK4CDK2SYKIGF1REGFR | |
| SCHEMBL6830002 | 0.76 | CDK1 (0.48) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL6829996 | 0.76 | CDK1 (0.48) | CDK4CDK2SYKCDK1IGF1R | |
| SCHEMBL29722547 | 0.76 | EGFR (0.78) | ITKEGFRJAK2LYNJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004046118-A2 | 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |