Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588105 | 0.82 | CHRM1 (0.46) | CHRM1GPR17PARP1PARP2PTGER1 | |
| SCHEMBL11398553 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1 | |
| SCHEMBL6946391 | 0.78 | CHRM1 (0.55) | CHRM1PRKAG1PRKAA2PRKAB1FFAR1 | |
| SCHEMBL7260713 | 0.78 | NPC1 (0.46) | PARP1NPC1RAB9ACNR2ALDH1A1 | |
| SCHEMBL15111647 | 0.78 | GAA (0.42) | PARP1NPC1RAB9AKDM4ECNR2 | |
| SCHEMBL6829325 | 0.77 | CHRM1 (0.46) | CHRM1GPR17PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL9589858 | 0.75 | CHRM1 (0.39) | CHRM1PARP1PARP2PTGER1PTGER4 | |
| SCHEMBL9591447 | 0.74 | MEN1 (0.43) | CHRM1GPR17KDM4ECNR2ALDH1A1 | |
| SCHEMBL9307952 | 0.74 | NPC1 (0.46) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5790951 | 0.74 | PARP1 (0.43) | CHRM1GPR17FFAR1PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108723-A1 | 4,5-DIHYDRO-IMIDAZO[4,5,1-II]QUINOLIN-6-ONES AS PARP INHIBITORS | ALTANA PHARMA AG (DE) | 2004-12-16 | — | — | WO | disclosed |
| WO-2003104233-A1 | 4,5-DIHYDRO-IMIDAZO (4,5,1-IJ) QUINOLIN-6-ONES DERIVATIVES AND THEIR USE AS POLY (ADP-RIBOSYL) TRANSFERASE (PARP) INHIBITORS | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |