Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.60 |
| ▸ | KDR | P35968 | 14/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830967 | 0.87 | SRC (0.67) | SRCKDREGFR | |
| SCHEMBL6829449 | 0.85 | SRC (0.60) | SRCKDREGFRALDH1A1CYP1A2 | |
| SCHEMBL6823529 | 0.85 | SRC (0.62) | SRCKDREGFR | |
| SCHEMBL6826661 | 0.84 | SRC (0.69) | SRCKDREGFR | |
| SCHEMBL7132585 | 0.84 | SRC (0.69) | SRCKDREGFR | |
| SCHEMBL7128347 | 0.83 | SRC (0.63) | SRCKDREGFR | |
| Hydrochloric Acid SCHEMBL6823476 | 0.82 | SRC (0.62) | SRCKDREGFR | |
| SCHEMBL3205180 | 0.82 | SRC (0.55) | SRCKDREGFR | |
| SCHEMBL6829839 | 0.81 | SRC (0.60) | SRCKDREGFR | |
| SCHEMBL3194306 | 0.80 | EGFR (0.46) | SRCKDREGFRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108710-A1 | 4-PYRIMIDINYL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | WO | disclosed |