Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 13/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.53 |
| ▸ | BCL6 | P41182 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.49 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.49 |
| ▸ | BUB1 | O43683 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13151491 | 0.87 | MAPK10 (0.62) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL1518963 | 0.84 | MAPK10 (0.59) | MAPK10MAPK8BCL6ROCK1MAPK14 | |
| SCHEMBL6829712 | 0.83 | MAPK10 (0.84) | MAPK10MAPK8MAPK14NPC1MAPT | |
| SCHEMBL1518773 | 0.83 | MAPK10 (0.57) | MAPK10MAPK8BCL6ROCK1MAPK14 | |
| SCHEMBL6923905 | 0.83 | MAPK10 (0.57) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL15202244 | 0.81 | MAPK10 (0.54) | MAPK10MAPK8BCL6ROCK1MAPK14 | |
| SCHEMBL23588551 | 0.80 | KCNH2 (0.58) | MAPK10MAPK8BCL6ROCK1CHEK1 | |
| SCHEMBL30216764 | 0.80 | KCNH2 (0.58) | MAPK10MAPK8BCL6ROCK1CHEK1 | |
| SCHEMBL1518966 | 0.80 | MAPK10 (0.56) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL1518621 | 0.80 | MAPK10 (0.67) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | claimed |
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |