Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 14/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.49 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904599 | 0.89 | MAPK10 (0.53) | MAPK10MAPK8MEN1KMT2AGFER | |
| SCHEMBL13151491 | 0.87 | MAPK10 (0.62) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL1518773 | 0.86 | MAPK10 (0.57) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL626575 | 0.85 | MEN1 (0.64) | MAPK10MEN1KMT2AGFERALDH1A1 | |
| SCHEMBL29582475 | 0.85 | MEN1 (0.64) | MAPK10MEN1KMT2AGFERALDH1A1 | |
| SCHEMBL15202244 | 0.84 | MAPK10 (0.54) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL1518963 | 0.84 | MAPK10 (0.59) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL31138002 | 0.83 | MEN1 (0.61) | MAPK10MEN1KMT2AGFERALDH1A1 | |
| SCHEMBL6830106 | 0.83 | MAPK10 (0.58) | MAPK10MAPK8MAPK14PIP5K1BPIP5K1C | |
| SCHEMBL6831731 | 0.82 | MAPK10 (0.53) | MAPK10MAPK8MAPK14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |