Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 14/20 | 0.63 |
| ▸ | AXL | P30530 | 5/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669865 | 0.95 | KDR (0.69) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL4668929 | 0.86 | KDR (0.64) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL4669693 | 0.85 | KDR (0.73) | KDRPDGFRAAXLFGFR2KIT | |
| Hydrochloric Acid SCHEMBL4668966 | 0.84 | KDR (0.71) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL1892120 | 0.81 | KDR (0.76) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL4669930 | 0.80 | KDR (0.70) | KDRPDGFRAAXLFGFR2KIT | |
| Hydrochloric Acid SCHEMBL4670112 | 0.80 | KDR (0.75) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL6831452 | 0.80 | AXL (0.57) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL1894464 | 0.80 | KDR (0.66) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL25779633 | 0.80 | KDR (0.83) | KDRPDGFRAAXLFGFR2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382604-A1 | QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-01-21 | — | — | EP | disclosed |